Blog Archives

Retrospective and Observational Comparative Effectiveness Studies

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Source: Tufts Clinical and Translational Science Institute

Type: Online Course

Level: Intermediate

Description: “After completing this lecture, you will be able to:
State the limitations of randomized controlled trials
Identify the settings in which observational studies of comparative effectiveness may be particularly helpful to clinicians and policymakers
Explain the methodological challenges in conducting retrospective, observational CER using existing sources of data
Describe model-based and other approaches to reduce the effects of confounding in observational CER
Discuss specific examples of retrospective and observational CER, and how these have informed public policy and healthcare delivery system change
List key aspects and the steps of a systematic review
Identify the methodological and inferential challenges of longitudinal observational studies of health outcomes and delivery system change”

Personalized Medicine, Heterogeneity of Treatment Effect, and Implications for Comparative Effectiveness

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Source: Tufts Clinical and Translational Science Institute

Type: Online Course

Level: Advanced

Description: “After completing this lecture, you will be able to:
Identify the limitations of applying the overall results of clinical trials to individual patients
Discuss how summary results of individual trials might not even reflect the benefits of typical patients in the trial
Explain how subgroup analyses are prone both to false-positive and false-negative results
Illustrate approaches that might lead to more credible and actionable subgroup results
Express why multidimensional risk models may have advantages over conventional “one-variable-at-a-time” subgroup analysis
Determine some of the limitations of using genetic information as a basis for exploring heterogeneity of treatment effect”

Comparative Effectiveness Trials and Assessing Pharmacogenetic Information in Clinical Trials

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Source: Tufts Clinical and Translational Science Institute

Type: Online Course

Level: Intermediate

Description: “After completing this lecture, you will be able to:
Identify the need for comparative effectiveness trials, even for drug therapies where “”proof of efficacy”" is already required prior to approval
Explain the differences between pragmatic/effectiveness trials and explanatory/efficacy trials
List the strengths and limitations of pragmatic versus explanatory designs
State the strengths and limitations of various types of outcome measures, including surrogate versus clinical outcomes
Explain the difference between prognostic and predictive genetic markers
Identify the pros and cons of alternative research designs for assessing pharmacogenetic (predictive) effects
Discuss “repurposed” randomized trials for assessing pharmacogenetic effects
Define empirical data”

Introduction: A Review of Evidence-Based Medicine (EBM) and a Framework for Understanding the CER Agenda

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Source: Tufts Clinical and Translational Science Institute

Type: Online Course

Level: Intermediate

Description: “After completing this lecture, you will be able to: List the principles of Evidence-Based Medicine (EBM), state how CER extends the principles of EBM, describe a framework for understanding the CER agenda, and identify the stakeholders of CER”.

Comparative Effectiveness Research: Recent History, Role in Healthcare Reform and Rationale for CER

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Source: Tufts Clinical and Translational Science Institute

Type: Online Course

Level: Intermediate

Description: “After completing this lecture, you will be able to:
Define CER based on standard definitions and the typical activities that it encompasses
Review the motivations, accomplishments, and impediments for CER
Describe how CER is supported in the United States now and how the new Patient-Centered Outcomes Research Institute will support CER
Identify the roles for CTSAs in facilitating and implementing CER
Discuss specific needs, next steps, and the future of CER
Identify the forces shaping national priorities for CER in the United States
Explain the current CER landscape in the United States
Compare and contrast comparative effectiveness and cost-effectiveness research”

The 1st Biennial Global Implementation Conference (GIC)

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Source: 3-C Institute for Social Development
Type: Online Course Materials

Level: Intermediate

Description:The 2011 Global Implementation Conference (GIC) brought together more than 750 scientists, policy makers, practitioners, and community and organizational leaders from around the world for an unprecedented focus on how evidence-based practices can be implemented effectively to improve outcomes for people and organizations.

Continuing Education Credits: N/A

Considerations of Research Design

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Source: Office for Human Research Protections (OHRP) Archive
Type: Website

Level: Basic

Description: Detailed analysis of structures and stages of research. Topics discussed include implementation and incremental study.

Continuing Education Credits: N/A

Good Clinical Practice: GCP Boot Camp (Part I & II)

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Source: The Rockefeller University, Center for Clinical and Translational Science

Type: Webcast

Level: Basic

Description: Two part course on good clinical practice by researchers from Rockefeller University.

Continuing Education Credits: N/A

NIH Course in Protecting Human Subject Research Participants

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Source: NIH Office of Extramural Research

Type: Online Course

Level: Basic

Description: NIH Web-based training course consisting of seven modules, and guidance that describe the implementation of those principle. Four of the modules are followed by a quiz.

Continuing Education Credits: N/A

NIH Grant Review Process

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Source: NIH Center for Scientific Review

Type: YouTube Videos

Level: Basic

Description: CSR has produced a series of videos to give you an inside look at how scientists from across the country review NIH grant applications for scientific and technical merit. New and established applicants will find insights and understanding that can empower them to improve the applications and increase their chances for receiving a more positive review.

Continuing Education Credits: N/A